Concanavalin A |
| Katalog-Nr.GC18572 |
Concanamycin A gehört zu den Concanamycinen, einer Familie von Makrolid-Antibiotika, die aus Streptomyces diastatochromogenes isoliert wurden und hochaktive und selektive Hemmstoffe der Vakuolären Protonen-ATPase (v-[H+]ATPase) sind.
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Cas No.: 11028-71-0
Sample solution is provided at 25 µL, 10mM.
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Concanamycin A belongs to the concanamycins, a family of macrolide antibiotics isolated from Streptomyces diastatochromogenes that are highly active and selective inhibitors of the vacuolar proton-ATPase (v-[H[+]]ATPase). Among them, concanamycin A is the most selective and potent inhibitor of the V-[H[+]]ATPase.[1]
n vitro study indicated that concanamycin A was active at 5 nM and completely blocked influenza virus infection at 10 nM in MDCK cells. Results showed that concanamycin A blocked viral replication by inhibiting the v-[H[+]]ATPase, thus preventing acidification of endosomes and release of virions into the cytoplasm. An early event in virus infection is the target of concanamytin A. In addition, the inhibition of the v-[H[+]]ATPase by concanamycin A prevents endosomal acidification, inhibiting virus release from endosomes.[1]
References:
[1].Rosario G. et al. Concanamycin A blocks influenza virus entry into cells under acidic conditions. FEBS Letters 1994 June; 349; 327-330.
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