(E/Z)-GO289 |
| Catalog No.GC62735 |
(E/Z)-GO289 es un inhibidor potente y selectivo de la caseÍna quinasa 2 (CK2) (IC50=7 nM). (E/Z)-GO289 alarga fuertemente el perÍodo circadiano. (E/Z)-GO289 exhibe una inhibiciÓn dependiente del tipo de célula del crecimiento de células cancerosas que se correlaciona con la funciÓn del reloj celular.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 694522-87-7
Sample solution is provided at 25 µL, 10mM.
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(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function[1].
(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1]. (E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].
[1]. Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.
| Cas No. | 694522-87-7 | SDF | |
| Formula | C17H15BrN4O2S | M.Wt | 419.3 |
| Solubility | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3849 mL | 11.9246 mL | 23.8493 mL |
| 5 mM | 0.477 mL | 2.3849 mL | 4.7699 mL |
| 10 mM | 0.2385 mL | 1.1925 mL | 2.3849 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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