18α-Glycyrrhetinic acid (Synonyms: Arthrodont, Biosone, Enoxolone, α-Glycyrrhetinic Acid, GM 1658, NSC 35347, PO 12, STX 352) |
Catalog No.GC35061
One-Click Copy Product Info
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18α-El ácido glicirretínico, un compuesto derivado de la dieta, es un inhibidor de NF-kB y un activador del proteasoma, que sirve como factor de prolongevidad y antiagregación en un organismo multicelular.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1449-05-4
Sample solution is provided at 25 µL, 10mM.
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18α-Glycyrrhetinic acid is a bioactive triterpenoid mainly derived from Glycyrrhiza radix. 18α-Glycyrrhetinic acid has various pharmacological activities such as anti-oxidative and anti-inflammatory[1]. 18α-Glycyrrhetinic acid can inhibit oxidative stress via activating Nrf-2 signaling[1].
18α-Glycyrrhetinic acid (8μM; 72h) inhibited cell growth in Human HSC cells[2]. 18α-Glycyrrhetinic acid (4μg/mL; 24h) significantly reduced ROS (reactive oxygen species) production in fructose-treated HK2 cells[3]. 18α-Glycyrrhetinic acid (50μM; 48h) decreased the cell viability in Caco-2 cells[4]. 18α-Glycyrrhetinic acid (2μg/mL; 24h) increased the cell viability in mitomycin C-induced HFL-1 cells[1].
18α-Glycyrrhetinic acid (10mg/kg; 30d; q2d; i.p.) significantly decreased the expression of CD40 and MHC-II molecules in BALB/c mice[5]. 18α-Glycyrrhetinic acid (12.5, 25 and 50mg/kg; 12 weeks; p.o.) alleviated fructose-induced renal injury in C57BL/6 mice[3].
References:[1] Lefaki M, Papaevgeniou N, Tur J A, et al. The dietary triterpenoid 18α-glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway [J]. Redox biology, 2020, 28: 101317.
[2] Zong L, Qu Y, Xu M Y, et al. 18α-Glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line [J]. Journal of digestive diseases, 2013, 14(6): 328-336.
[3] Cheng X, Qiu L, Wang F. 18α-Glycyrrhetinic acid (GA) ameliorates fructose-induced nephropathy in mice by suppressing oxidative stress, dyslipidemia and inflammation [J]. Biomedicine & pharmacotherapy, 2020, 125: 109702.
[4] Malekinejad M, Pashaee M R, Malekinejad H. 18β-Glycyrrhetinic acid altered the intestinal permeability in the human Caco-2 monolayer cell model [J]. European journal of nutrition, 2022, 61(7): 3437-3447.
[5] Ebrahimnezhad S, Amirghofran Z, Karimi M H. Decline in immunological responses mediated by dendritic cells in mice treated with 18α-glycyrrhetinic acid [J]. Immunological investigations, 2016, 45(3): 191-204.
| Cell experiment [1]: | |
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Cell lines |
Human HSC cell line |
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Preparation Method |
2×104 cells per well were seeded onto 24-well plates and incubated overnight. After starvation for 24h, the cells were subsequently stimulated with 10% FBS with or without the presence of 18α-Glycyrrhetinic acid. The number of cells was determined by computer-equipped cell counter 72h after treated with 18α-Glycyrrhetinic acid. |
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Reaction Conditions |
8μM; 72h |
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Applications |
18α-Glycyrrhetinic acid inhibited cell growth. |
| Animal experiment [2]: | |
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Animal models |
BALB/c mice |
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Preparation Method |
18α-Glycyrrhetinic acid solution was prepared in DMSO. A concentration of 10mg 18α-Glycyrrhetinic acid per kilogram of each mouse was used to be intraperitoneally injected in test group every other day within 30 consecutive days. The mice in the control group were treated with 2% DMSO (equal to the test group) as a vehicle in PBS. The expression of co-stimulatory molecules CD40 and MHC-II on isolated dendritic cells from mice were investigated by flow cytometry. |
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Dosage form |
10mg/kg; 30d; q2d; i.p. |
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Applications |
18α-Glycyrrhetinic acid significantly decreased the expression of CD40 and MHC-II molecules. |
| References: [1] Zong L, Qu Y, Xu M Y, et al. 18α-Glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line [J]. Journal of digestive diseases, 2013, 14(6): 328-336. [2] Ebrahimnezhad S, Amirghofran Z, Karimi M H. Decline in immunological responses mediated by dendritic cells in mice treated with 18α-glycyrrhetinic acid [J]. Immunological investigations, 2016, 45(3): 191-204. | |
| Cas No. | 1449-05-4 | SDF | |
| Sinónimos | Arthrodont, Biosone, Enoxolone, α-Glycyrrhetinic Acid, GM 1658, NSC 35347, PO 12, STX 352 | ||
| Canonical SMILES | CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]([C@@](CC[C@]3(C)[C@]4([H])C[C@@](C)(C(O)=O)CC3)(C)C4=C5)(C)[C@]2([H])C5=O | ||
| Formula | C30H46O4 | M.Wt | 470.68 |
| Solubility | DMF: 13 mg/ml,DMSO: 16 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH7.2) (1:7): 0.13 mg/ml | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1246 mL | 10.6229 mL | 21.2459 mL |
| 5 mM | 424.9 μL | 2.1246 mL | 4.2492 mL |
| 10 mM | 212.5 μL | 1.0623 mL | 2.1246 mL |
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)