E3 ligase Ligand 16 (Synonyms: MDM2 ligand 1; E3 ligase Ligand 16) |
| Catalog No.GC35930 |
E3 ligase Ligand 16 (MDM2 ligand 1) es el ligando MDM2 basado en Nutlin 3. El ligando 16 de E3 ligasa se puede conectar al ligando para proteÍna mediante un conector para formar PROTAC.
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Cas No.: 2249750-27-2
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 16 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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