E3 ligase Ligand 16 (Synonyms: MDM2 ligand 1; E3 ligase Ligand 16) |
| Catalog No.GC35930 |
E3 리가제 리간드 16(MDM2 리간드 1)은 Nutlin 3 기반 MDM2 리간드입니다. E3 리가제 리간드 16은 링커에 의해 단백질용 리간드에 연결되어 PROTAC을 형성할 수 있습니다.
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Cas No.: 2249750-27-2
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 16 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 16 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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