VU6005806 (Synonyms: AZN-00016130) |
| Catalog No.GC37932 |
VU6005806 (AZN-00016130) es un potente modulador alostérico positivo (PAM) del subtipo 4 (M4) del receptor muscarnico de acetilcolina, con CE50 de 94 nM, 28 nM, 87 nM y 68 nM para humanos, ratas, perros y cyno M4, respectivamente.
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Cas No.: 2180914-37-6
Sample solution is provided at 25 µL, 10mM.
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VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.
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