VU6005806 (Synonyms: AZN-00016130) |
| カタログ番号GC37932 |
VU6005806 (AZN-00016130) は、強力なムスカルニック アセチルコリン受容体サブタイプ 4 (M4) 正のアロステリック モジュレーター (PAM) であり、EC50 は、ヒト、ラット、イヌ、およびカニクイザル M4 に対してそれぞれ 94 nM、28 nM、87 nM、および 68 nM です。
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Cas No.: 2180914-37-6
Sample solution is provided at 25 µL, 10mM.
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VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.
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