VU6005806 (Synonyms: AZN-00016130) |
| Catalog No.GC37932 |
VU6005806(AZN-00016130)은 인간, 쥐, 개 및 사이노 M4에 대해 각각 94nM, 28nM, 87nM 및 68nM의 EC50을 갖는 강력한 무스카닉 아세틸콜린 수용체 아형 4(M4) 양성 알로스테릭 조절제(PAM)입니다.
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Cas No.: 2180914-37-6
Sample solution is provided at 25 µL, 10mM.
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VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.
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