Glaucocalyxin A |
| Catalog No.GC38606 |
La glaucocalyxina A, un diterpeno ent-kauranoide de Rabdosia japonica var., induce la apoptosis en el osteosarcoma al inhibir la translocaciÓn nuclear del dedo de cinco zinc Glis 1 (GLI1) mediante la regulaciÓn de la vÍa de seÑalizaciÓn PI3K/Akt. La glaucocalixina A tiene efecto antitumoral.
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Cas No.: 79498-31-0
Sample solution is provided at 25 µL, 10mM.
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Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect[1].
Glaucocalyxin A induces apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3[1].
[1]. Zhu J, et al. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nucleartranslocation via regulating PI3K/Akt pathway. Cell Death Dis. 2018 Jun 13;9(6):708.
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