GPNA hydrochloride |
| Catalog No.GC39489 |
El clorhidrato de GPNA es un sustrato bien conocido de la enzima γ-glutamiltransferasa (GGT). El clorhidrato de GPNA es un inhibidor especÍfico de ASCT2 del transportador de glutamina (Gln). El clorhidrato de GPNA también inhibe los transportadores dependientes de Na+-, como la familia SNAT (SNAT1/2/4/5), y los transportadores de leucina independientes de Na+- LAT1/2. GPNA induce reversiblemente la apoptosis en células A549.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 67953-08-6
Sample solution is provided at 25 µL, 10mM.
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GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].
[1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.
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