GPNA hydrochloride |
| Catalog No.GC39489 |
Le chlorhydrate de GPNA est un substrat bien connu de l'enzyme γ-glutamyltransférase (GGT). Le chlorhydrate de GPNA est un inhibiteur spécifique de l'ASCT2 du transporteur de la glutamine (Gln). Le chlorhydrate de GPNA inhibe également les transporteurs dépendants de Na+-, tels que la famille SNAT (SNAT1/2/4/5), et les transporteurs de leucine indépendants de Na+- LAT1/2. Le GPNA induit de manière réversible l'apoptose des cellules A549.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 67953-08-6
Sample solution is provided at 25 µL, 10mM.
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GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].
[1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.
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