GPNA hydrochloride |
| Katalog-Nr.GC39489 |
GPNA-Hydrochlorid ist ein gut bekanntes Substrat des Enzyms γ-Glutamyltransferase (GGT). GPNA-Hydrochlorid ist ein spezifischer Glutamin (Gln)-Transporter-ASCT2-Inhibitor. GPNA-Hydrochlorid hemmt auch Na+--abhÄngige TrÄger wie die SNAT-Familie (SNAT1/2/4/5) und die Na+--unabhÄngigen Leucintransporter LAT1/2. GPNA induziert reversibel Apoptose in A549-Zellen.
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Cas No.: 67953-08-6
Sample solution is provided at 25 µL, 10mM.
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GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].
[1]. Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9(1):891.
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