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HNMPA-(AM)3

Catalog No.GC18888 Copy One-Click Copy Product Info

HNMPA-(AM)3 es un anÁlogo inhibidor de la tirosina quinasa del receptor de insulina permeable a las células y selectivo de HNMPA.

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HNMPA-(AM)3 Chemical Structure

Cas No.: 120944-03-8

Tamaño Precio Disponibilidad Cantidad
5mg
198,00 $
Disponible
10mg
347,00 $
Disponible
25mg
743,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.



Description of HNMPA-(AM)3

HNMPA-(AM)3 is a cell-permeable prodrug form of the insulin receptor tyrosine kinase (IRTK) inhibitor HNMPA . HNMPA-(AM)3 inhibits IRTK autophosphorylation in CHO cells expressing the human receptor in a concentration- and time-dependent manner. It inhibits 2-deoxyglucose uptake but does not affect insulin-stimulated thymidine uptake in CHO cells at concentrations up to 100 μM.

Chemical Properties of HNMPA-(AM)3

Cas No. 120944-03-8 SDF
Chemical Name P-[[(acetyloxy)methoxy]-2-naphthalenylmethyl]-phosphonic acid, bis[(acetyloxy)methyl] ester
Canonical SMILES CC(OCOC(P(OCOC(C)=O)(OCOC(C)=O)=O)C1=CC2=CC=CC=C2C=C1)=O
Formula C20H23O10P M.Wt 454.4
Solubility DMF: 15 mg/ml,DMSO: 1 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 1 mg/ml Storage Store at 2-8°C,protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of HNMPA-(AM)3

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.2007 mL 11.0035 mL 22.007 mL
5 mM 440.1 μL 2.2007 mL 4.4014 mL
10 mM 220.1 μL 1.1004 mL 2.2007 mL
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In vivo Formulation Calculator (Clear solution) of HNMPA-(AM)3

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Review for HNMPA-(AM)3

Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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