L-Ascorbic Acid 2-phosphate (magnesium salt) (Synonyms: AA2P, Ascorbyl PM, Phospitan C) |
Catalog No.GC19511
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L-Ascorbic Acid 2-phosphate (magnesium salt) es un derivado estable de VC(vitamina C).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 113170-55-1
Sample solution is provided at 25 µL, 10mM.
L-Ascorbic Acid 2-phosphate (magnesium salt) es un derivado estable de VC(vitamina C)[1].Puede estimular la expresión y formación de colágeno[2].
L-Ascorbic Acid 2-phosphate (magnesium salt) (100-500μM; 24 h) atenúa la apoptosis inducida por MeHg al aliviar el daño del ADN medidado por ROS en las células SH-SY5Y[3]. L-Ascorbic Acid 2-phosphate (magnesium salt) (0.25-1mM) reprimió la expresión de la proteína dickkopf-1 inducible por DHT(DKK-1) inducida ppor DHT[4]. L-Ascorbic Acid 2-phosphate (magnesium salt) (250μM; 5-60min)con FGF-2 indujo una proliferación óptima de las células madre mesenquimales de médula ósea humana(BMSC) y aumentó la tasa de acumulación de número deBMSC durante un período de cultivo de 2 meses[5].El ARNm de IGF-1 en el medio acondicionado de las células DP aumentó significativamente después del tratamiento con L-Ascorbic Acid 2-phosphate (magnesium salt),inducible IGF-1 por L-Ascorbic Acid 2-phosphate (magnesium salt) de las células DP promueve la proliferación de queratinocitos foliculares y estimula el crecimiento del folículo piloso fuera del cuerpo a través de PI3K[6].
L-Ascorbic Acid 2-phosphate (magnesium salt) regula las interacciones mesenquimal-epiteliales en el folículo piloso y promueve el crecimiento del cabello en modelos de los ratones[7].
References:
[1]. Spiclin P, Homar M, et,al. Sodium ascorbyl phosphate in topical microemulsions. Int J Pharm. 2003 Apr 30;256(1-2):65-73. doi: 10.1016/s0378-5173(03)00063-2. PMID: 12695012.
[2]. Shima N, Kimoto M, et,al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate. Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. doi: 10.1167/iovs.11-7592. PMID: 21980003.
[3]. Zuo K, Xu Q, et,al. L-Ascorbic Acid 2-Phosphate Attenuates Methylmercury-Induced Apoptosis by Inhibiting Reactive Oxygen Species Accumulation and DNA Damage in Human SH-SY5Y Cells. Toxics. 2023 Feb 2;11(2):144. doi: 10.3390/toxics11020144. PMID: 36851019; PMCID: PMC9967424.
[4]. Kwack MH, Kim MK, et,al. L-ascorbic acid 2-phosphate represses the dihydrotestosterone-induced dickkopf-1 expression in human balding dermal papilla cells. Exp Dermatol. 2010 Dec;19(12):1110-2. doi: 10.1111/j.1600-0625.2010.01143.x. PMID: 20701628.
[5]. Bae SH, Ryu H, et,al. L-ascorbic acid 2-phosphate and fibroblast growth factor-2 treatment maintains differentiation potential in bone marrow-derived mesenchymal stem cells through expression of hepatocyte growth factor. Growth Factors. 2015 Apr;33(2):71-8. doi: 10.3109/08977194.2015.1013628. Epub 2015 Feb 25. PMID: 25714612.
[6]. Kwack MH, Shin SH, et,al. l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase. Br J Dermatol. 2009 Jun;160(6):1157-62. doi: 10.1111/j.1365-2133.2009.09108.x. Epub 2009 Mar 26. PMID: 19416266.
[7]. Sung YK, Hwang SY, et,al. The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting Vitamin C derivative. J Dermatol Sci. 2006 Feb;41(2):150-2. doi: 10.1016/j.jdermsci.2005.11.010. Epub 2006 Jan 9. PMID: 16406749.
| Experimentos celulares [1]: | |
Líneas celulares | Las células SH-SY5Y |
Método de preparación | Las células SH-SY5Y se prepararon primero con 100-500 μM L-Ascorbic Acid 2-phosphate en 1×PBS y se trataron con 1 μM MeHg durante 24 h. |
Condiciones de reacción | 100-500μM; 24 h |
Áreas de aplicación | L-Ascorbic Acid 2-phosphate (magnesium salt) disminuye la acumulación de ROS inducida por MeHg en las células de una manera dependiente de la dosis. |
| Experimentos con animales [2]: | |
Modelos animales | Los ratones C57BL/6 |
Método de preparación | Los pieles de la espalda de los ratones se afeitaron alas 7 semanas de edad (etapa telógena) y luego se aplicó ácido L-ascórbico 2-fosfato a 250mM mediante iontoforesis.Se adaptó el sistema de iontoforesis único,que proporciona una corriente eléctrica constante de 0,1-1,0 mA/cm2 en áreas.La lontoforesis se realizó durante 15 min a corrientes constantes de 0,2-0,4 mV diariamente durante 4 semanas. |
Áreas de aplicación | L-Ascorbic Acid 2-phosphate (magnesium salt) regula las interacciones mesenquimal-epiteliales en el folículo piloso y promueve el crecimiento del cabello en modelos de los ratones. |
References: [1]. Zuo K, Xu Q, et,al. L-Ascorbic Acid 2-Phosphate Attenuates Methylmercury-Induced Apoptosis by Inhibiting Reactive Oxygen Species Accumulation and DNA Damage in Human SH-SY5Y Cells. Toxics. 2023 Feb 2;11(2):144. doi: 10.3390/toxics11020144. PMID: 36851019; PMCID: PMC9967424. [2]. Sung YK, Hwang SY, et,al. The hair growth promoting effect of ascorbic acid 2-phosphate, a long-acting Vitamin C derivative. J Dermatol Sci. 2006 Feb;41(2):150-2. doi: 10.1016/j.jdermsci.2005.11.010. Epub 2006 Jan 9. PMID: 16406749. | |
| Cas No. | 113170-55-1 | SDF | |
| Sinónimos | AA2P, Ascorbyl PM, Phospitan C | ||
| Chemical Name | L-Ascorbic acid is essential for the synthesis of collagen | ||
| Canonical SMILES | O=C1C(OP([O-])([O-])=O)=C([C@]([H])(O1)[C@H](CO)O)[O-].O=C2C(OP([O-])([O-])=O)=C([C@]([H])(O2)[C@H](CO)O)[O-].[Mg+2].[Mg+2].[Mg+2] GC47538: O=C1C(OP([O-])([O-])=O)=C([C@]([H])(O1)[C@H](CO)O)[O-].O=C2C(OP([O-])([O-])=O)=C([C@]([H])(O2)[C@H](CO)O)[O-].[Mg+2].[Mg+2].[Mg+2] | ||
| Formula | C6H6O9P • 1.5Mg | M.Wt | 289.5 |
| Solubility | Water:25mg/ml | Storage | Store at 2-8°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4542 mL | 17.2712 mL | 34.5423 mL |
| 5 mM | 690.8 μL | 3.4542 mL | 6.9085 mL |
| 10 mM | 345.4 μL | 1.7271 mL | 3.4542 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)