MM-589 TFA |
| Catalog No.GC65037 |
MM-589 TFA es un potente inhibidor de la interacciÓn proteÍna-proteÍna del dominio de repeticiÓn 5 de WD (WDR5) y la leucemia de linaje mixto (MLL). MM-589 se une a WDR5 con una IC50 de 0,90 nM e inhibe la actividad de la metiltransferasa MLL H3K4 con una IC50 de 12,7 nM.
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Cas No.: 2097887-21-1
Sample solution is provided at 25 µL, 10mM.
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MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].
MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.
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