MM-589 TFA |
| Catalog No.GC65037 |
Le MM-589 TFA est un puissant inhibiteur de l'interaction protéine-protéine du domaine de répétition WD (WDR5) et de la leucémie de lignée mixte (MLL). Le MM-589 se lie au WDR5 avec une IC50 de 0,90 nM et inhibe l'activité de la méthyltransférase MLL H3K4 avec une IC50 de 12,7 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2097887-21-1
Sample solution is provided at 25 µL, 10mM.
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MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].
MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.
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