MRTX-EX185 |
| Catalog No.GC64452 |
MRTX-EX185 es un potente inhibidor de KRAS y KRAS(G12D) cargados con GDP, con una IC50 de 90 nM para KRAS(G12D). MRTX-EX185 también se une a HRAS con carga de PIB.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS[1].
[1]. Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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