MRTX-EX185 |
| カタログ番号GC64452 |
MRTX-EX185 は、GDP 搭載 KRAS および KRAS(G12D) の強力な阻害剤であり、KRAS(G12D) の IC50 は 90 nM です。 MRTX-EX185 は、GDP を搭載した HRAS にも結合します。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS[1].
[1]. Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21.
Review for MRTX-EX185
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for MRTX-EX185
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