MRTX-EX185 |
Katalog-Nr.GC64452 |
MRTX-EX185 ist ein potenter Inhibitor von GDP-beladenem KRAS und KRAS(G12D) mit einem IC50 von 90 nM fÜr KRAS(G12D). MRTX-EX185 bindet auch GDP-beladene HRAS.
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Sample solution is provided at 25 µL, 10mM.
MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS[1].
[1]. Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21.
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(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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