MRZ 2-514 |
| Catalog No.GC31036 |
MRZ 2-514 es un antagonista del sitio modulador insensible a la estricnina del receptor NMDA (glicinaB), con Ki de 33 μM.
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Cas No.: 202808-11-5
Sample solution is provided at 25 µL, 10mM.
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MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.
MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM[1].
MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid[1].
[1]. Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275
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