Pimonidazole (Synonyms: NSC 380540, Ro 038799) |
| Catalog No.GC41338 |
El pimonidazol es un nuevo marcador de hipoxia para el estudio complementario de la hipoxia tumoral y la proliferaciÓn celular en el tumor. El pimonidazol se acumula en las células hipÓxicas a través de la uniÓn covalente con macromoléculas o mediante la formaciÓn de metabolitos reductores después de la reducciÓn de su grupo nitro, puede usarse para la evaluaciÓn cualitativa y cuantitativa de la hipoxia tumoral.
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Cas No.: 70132-50-2
Sample solution is provided at 25 µL, 10mM.
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Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck.[1] This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
Reference:
[1]. Kaanders, J.H.A.M., Wijffels, K.I.E.M., Marres, H.A.M., et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Research 62, 7066-7074 (2002).
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