Pimonidazole (Synonyms: NSC 380540, Ro 038799) |
| Catalog No.GC41338 |
Pimonidazole은 종양 저산소증과 종양의 세포 증식에 대한 보완 연구를 위한 새로운 저산소증 마커입니다. Pimonidazole은 거대 분자와의 공유 결합을 통해 저산소 세포에 축적되거나 니트로 그룹의 환원 후 환원 대사 산물을 형성하여 종양 저산소증의 정성 및 정량 평가에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70132-50-2
Sample solution is provided at 25 µL, 10mM.
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Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck.[1] This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.
Reference:
[1]. Kaanders, J.H.A.M., Wijffels, K.I.E.M., Marres, H.A.M., et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Research 62, 7066-7074 (2002).
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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