PROTAC Mcl1 degrader-1 |
| Catalog No.GC38943 |
PROTAC Mcl1 degradador-1 (compuesto C3), una quimera dirigida a la proteÓlisis (PROTAC) basada en el ligando Cereblon, es un inhibidor potente y selectivo de Mcl-1 (miembro de la familia Bcl-2) con una IC50 de 0,78 μM. PROTAC Mcl1 degradador-1 induce la ubiquitinaciÓn y la degradaciÓn proteasomal de Mcl-1 mediante la introducciÓn del ligando de uniÓn a E3 ligasa cereblon (CRBN) pomalidomida al inhibidor de Mcl-1 S1-6 con afinidad en el rango de μM.
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Cas No.: 2163793-38-0
Sample solution is provided at 25 µL, 10mM.
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PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1].
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
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