(R)-DNMDP |
| Catalog No.GC60002 |
(R)-DNMDP es un agente citotÓxico de células cancerosas potente y selectivo. (R)-DNMDP, la forma R de DNMDP, se une directamente a PDE3A. (R)-DNMDP tiene una EC50 500 veces menor en comparaciÓn con el enantiÓmero (S) en la lÍnea celular HeLa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1630760-60-9
Sample solution is provided at 25 µL, 10mM.
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(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12)[1][2].
[1]. de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8. Nat Chem Biol. 2016 Feb;12(2):102-8. [2]. Luc DE WAAL, et al. Compositions and methods for cancer expressing pde3a or slfn12. WO2017027854A1.
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