(R)-DNMDP |
| Catalog No.GC60002 |
(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC50 compared to the (S)-enantiomer in HeLa cell line.
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Cas No.: 1630760-60-9
Sample solution is provided at 25 µL, 10mM.
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(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12)[1][2].
[1]. de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8. Nat Chem Biol. 2016 Feb;12(2):102-8. [2]. Luc DE WAAL, et al. Compositions and methods for cancer expressing pde3a or slfn12. WO2017027854A1.
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