TASP 0390325 |
| Catalog No.GC50246 |
TASP 0390325 es un antagonista del receptor de arginina vasopresina 1B (receptor V1B) de alta afinidad y activo por vía oral con actividades antidepresivas y ansiolíticas.
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Cas No.: 1642187-96-9
Sample solution is provided at 25 µL, 10mM.
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Potent and selective V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor). Exhibits no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. Increases ACTH levels in rats. Orally bioavailable. Antidepressant and anxiolytic.
Iijima et al (2014) Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Br J Pharmacol. 171 3511 PMID:24654684
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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