TASP 0390325 |
| Catalog No.GC50246 |
TASP 0390325 est un antagoniste du récepteur 1B de l'arginine vasopressine (récepteur V1B) de haute affinité et actif par voie orale avec des activités antidépressives et anxiolytiques.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1642187-96-9
Sample solution is provided at 25 µL, 10mM.
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Potent and selective V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor). Exhibits no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. Increases ACTH levels in rats. Orally bioavailable. Antidepressant and anxiolytic.
Iijima et al (2014) Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Br J Pharmacol. 171 3511 PMID:24654684
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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