Tempo
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| Catalog No.GC39512 |
Tempo es un radical nitrÓxido clÁsico y es un eliminador selectivo de ROS que dismuta el superÓxido en el ciclo catalÍtico. Tempo induce la rotura de la cadena de ADN. Tempo se puede utilizar como organocatalizador para la oxidaciÓn de alcoholes primarios a aldehÍdos. Tempo tiene efectos mutagénicos y antioxidantes.
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Cas No.: 2564-83-2
Sample solution is provided at 25 µL, 10mM.
Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].
[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. [4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.
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