Tempo
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| Catalog No.GC39512 |
Tempo est un radical nitroxyde classique et est un piégeur sélectif de ROS qui dismutases superoxyde dans le cycle catalytique. Tempo induit la rupture des brins d'ADN. Tempo peut être utilisé comme organocatalyseur pour l'oxydation des alcools primaires en aldéhydes. Tempo a des effets mutagènes et antioxydants.
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Cas No.: 2564-83-2
Sample solution is provided at 25 µL, 10mM.
Tempo is a classic nitroxide radical and is a selective scavenger of mitochondrial ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[1][2][3][4].
[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. [2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. [3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22. [4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.
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