TRAF-STOP inhibitor 6877002 |
| Catalog No.GC38868 |
El inhibidor de TRAF-STOP 6877002, es un inhibidor selectivo de la interacciÓn CD40-TRAF6, compuesto VII, muestra inhibiciÓn de la activaciÓn de NF-κB en células RAW, extraÍdo de la patente WO2014033122A1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 433249-94-6
Sample solution is provided at 25 µL, 10mM.
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TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].
[1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.
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