Azido-PEG8-NHS ester |
| رقم الكتالوجGC61857 |
Azido-PEG8-NHS ester عبارة عن رابط PEG ADC قابل للانقسام مكون من 8 وحدات يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)Azido-PEG8-NHS ester هو أيضًا رابط PROTAC قائم على PEG و Alkyl / ether والذي يمكن استخدامه في تخليق PROTACs
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Cas No.: 1204834-00-3
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References:
[1]. Mahendra Persaud Deonarain, et al. Biological materials and uses thereof. WO2016046574A1.
[2]. Rong Yuan, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Analytical Chemistry (Washington, DC, United States) (2019), 91(8), 4948-4952.
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