Azido-PEG8-NHS ester |
| Catalog No.GC61857 |
Azido-PEG8-NHS 에스테르는 항체-약물 접합체(ADC)의 합성에 사용되는 절단 가능한 8개 단위 PEG ADC 링커입니다. Azido-PEG8-NHS 에스테르는 또한 PROTAC 합성에 사용할 수 있는 PEG 및 알킬/에테르 기반 PROTAC 링커입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1204834-00-3
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References:
[1]. Mahendra Persaud Deonarain, et al. Biological materials and uses thereof. WO2016046574A1.
[2]. Rong Yuan, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Analytical Chemistry (Washington, DC, United States) (2019), 91(8), 4948-4952.
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