Hematein |
| رقم الكتالوجGC39266 |
الهيماتين هو منتج أكسدة للهيماتوكسيلين يعمل كصبغةالهيماتين هو مثبط خيفي الكازين كيناز II مع IC 50 من 0.74 ميكرومترالهيماتين يثبط الفسفرة Akt / PKB Ser129 ، مسار Wnt / TCF ويزيد موت الخلايا المبرمج في خلايا سرطان الرئة
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Cas No.: 475-25-2
Sample solution is provided at 25 µL, 10mM.
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Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].
[1]. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169. [2]. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22.
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