Hematein |
| Catalog No.GC39266 |
헤마테인은 염료로 작용하는 헤마톡실린의 산화 생성물입니다. 헤마테인은 IC50이 0.74μM인 알로스테릭 카제인 키나제 II 억제제입니다. 헤마테인은 Wnt/TCF 경로인 Akt/PKB Ser129 인산화를 억제하고 폐암 세포에서 세포자멸사를 증가시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 475-25-2
Sample solution is provided at 25 µL, 10mM.
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Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].
[1]. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169. [2]. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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