Hematein |
| Catalog No.GC39266 |
La hemateÍna es un producto de oxidaciÓn de la hematoxilina que actÚa como colorante. La hemateÍna es un inhibidor alostérico de la caseÍna cinasa II con una IC50 de 0,74 μM. La hemateÍna inhibe la fosforilaciÓn de Akt/PKB Ser129, la vÍa Wnt/TCF y aumenta la apoptosis en las células de cÁncer de pulmÓn.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 475-25-2
Sample solution is provided at 25 µL, 10mM.
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Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].
[1]. Shirai, K., & Matsuoka, M. (1996). Structure and properties of hematein derivatives. Dyes and Pigments, 32(3), 159-169. [2]. Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43(5):1517-22.
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