CPTH2 |
| Catalog No.GC39365 |
CPTH2 es un potente inhibidor de histona acetiltransferasa (HAT). CPTH2 inhibe selectivamente la acetilaciÓn de la histona H3 por Gcn5. CPTH2 induce la apoptosis y disminuye la invasividad de una lÍnea celular de carcinoma renal de células claras (ccRCC) a través de la inhibiciÓn de la acetiltransferasa p300 (KAT3B).
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Cas No.: 357649-93-5
Sample solution is provided at 25 µL, 10mM.
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CPTH2 is a potent histone acetyltransferase (HAT) inhibitor and selectively inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
[1]. Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44. [2]. Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6.
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