Indirubin-3'-monoxime-5-sulphonic acid |
| رقم الكتالوجGC36312 |
Indirubin-3' ؛-monoxime-5-sulphonic acid هو مثبط قوي وانتقائي لـ CDK1 و CDK5 و GSK-3β ؛ مع IC50s من 5 نانومتر ، 7 نانومتر ، و 80 نانومتر ، على التوالي.
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Cas No.: 331467-05-1
Sample solution is provided at 25 µL, 10mM.
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Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1]. CDK1|5 nM (IC50)|CDK5|7 nM (IC50)|GSK-3β|80 nM (IC50)
[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.
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