PT2977 (Synonyms: PT2977; MK-6482) |
رقم الكتالوجGC37034 |
PT2977 (PT2977) هو HIF-2α نشط شفهيًا وانتقائيًا ؛ مثبط مع IC 50 من 9 نانومتر. PT2977 ، باعتباره الجيل الثاني من HIF-2α ؛ مثبط ، يزيد من الفاعلية ويحسن الصورة الحركية الدوائية. PT2977 هو علاج محتمل لسرطان الخلايا الكلوية الصافية (ccRCC).
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Cas No.: 1672668-24-4
Sample solution is provided at 25 µL, 10mM.
PT2977 is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for Clear cell renal cell carcinoma (ccRCC) and von Hippel-Lindau (VHL) disease[1]. IC50: 9 nM (HIF-2α)[1]
PT2977 potently and dose-dependently reduces mRNA levels of human cyclin D1, a target gene regulated by HIF-2α, and leads to rapid and dose-dependent reduction in EPO expression[1].
[1]. Xu R, et al. 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma. J Med Chem. 2019 Aug 8;62(15):6876-6893.
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