Tefinostat (Synonyms: CHR-2845) |
| رقم الكتالوجGC37753 |
Tefinostat (CHR-2845) هو مثبط للهيستون ديستيلاز (HDAC) وحيدة الخلية / بلاعميمكن شطر التيفينوستات إلى حمض نشط CHR-2847 بواسطة إستراز الكاربوكسيل إستيراز البشري داخل الخلايا -1 (hCE-1)يمكن استخدام Tefinostat للبحث عن اللوكيميا
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Cas No.: 914382-60-8
Sample solution is provided at 25 µL, 10mM.
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Tefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity[1]. HDAC
[1]. Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62.
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