Tefinostat (Synonyms: CHR-2845) |
| Katalog-Nr.GC37753 |
Tefinostat (CHR-2845) ist ein auf Monozyten/Makrophagen gerichteter Histon-Deacetylase (HDAC)-Hemmer. Tefinostat kann durch die intrazellulÄre Esterase humane Carboxylesterase-1 (hCE-1) in die aktive SÄure CHR-2847 gespalten werden. Tefinostat kann zur Erforschung von LeukÄmien eingesetzt werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 914382-60-8
Sample solution is provided at 25 µL, 10mM.
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Tefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity[1]. HDAC
[1]. Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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