Tefinostat (Synonyms: CHR-2845) |
| Catalog No.GC37753 |
Le tefinostat (CHR-2845) est un inhibiteur de l'histone désacétylase (HDAC) ciblée sur les monocytes/macrophages. Le téfinostat peut être clivé en acide actif CHR-2847 par l'estérase intracellulaire humaine carboxylestérase-1 (hCE-1). Tefinostat peut être utilisé pour la recherche de leucémies.
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Cas No.: 914382-60-8
Sample solution is provided at 25 µL, 10mM.
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Tefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity[1]. HDAC
[1]. Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62.
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