Tefinostat (Synonyms: CHR-2845) |
Catalog No.GC37753 |
Tefinostat(CHR-2845)는 단핵구/대식세포 표적 히스톤 데아세틸라제(HDAC) 억제제입니다. 테피노스타트는 세포내 에스테라제 인간 카르복실에스테라제-1(hCE-1)에 의해 활성산 CHR-2847로 절단될 수 있습니다. 테피노스타트는 백혈병 연구에 사용할 수 있습니다.
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Cas No.: 914382-60-8
Sample solution is provided at 25 µL, 10mM.
Tefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity[1]. HDAC
[1]. Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62.
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