KDOAM-25 citrate |
رقم الكتالوجGC38709 |
سيترات KDOAM-25 عبارة عن مثبط قوي ومانع للميثيل ليسين هيستون 5 (KDM5) مع IC50s 71 نانومتر ، 19 نانومتر ، 69 نانومتر ، 69 نانومتر لـ KDM5A ، KDM5B ، KDM5C ، KDM5D ، على التوالييزيد سترات KDOAM-25 من مثيلة H3K4 العالمية في مواقع بدء النسخ ويضعف الانتشار في خلايا المايلوما المتعددة MM1S
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Sample solution is provided at 25 µL, 10mM.
KDOAM-25 citrate is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].
[1]. Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.
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