KDOAM-25 citrate |
| Catalog No.GC38709 |
Le citrate de KDOAM-25 est un inhibiteur puissant et hautement sélectif des histones lysine déméthylases 5 (KDM5) avec des IC50 de 71 nM, 19 nM, 69 nM, 69 nM pour KDM5A, KDM5B, KDM5C, KDM5D, respectivement. Le citrate de KDOAM-25 augmente la méthylation globale de H3K4 au niveau des sites d'initiation de la transcription et altère la prolifération dans les cellules MM1S du myélome multiple.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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KDOAM-25 citrate is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].
[1]. Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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