KDOAM-25 citrate |
| Katalog-Nr.GC38709 |
KDOAM-25-Citrat ist ein potenter und hochselektiver Inhibitor der Histon-Lysin-Demethylase 5 (KDM5) mit IC50-Werten von 71 nM, 19 nM, 69 nM, 69 nM fÜr KDM5A, KDM5B, KDM5C bzw. KDM5D. KDOAM-25-Citrat erhÖht die globale H3K4-Methylierung an Transkriptionsstartstellen und beeintrÄchtigt die Proliferation in MM1S-Zellen des multiplen Myeloms.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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KDOAM-25 citrate is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].
[1]. Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.
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