KDOAM-25 citrate |
| カタログ番号GC38709 |
KDOAM-25 クエン酸塩は、KDM5A、KDM5B、KDM5C、KDM5D に対してそれぞれ 71 nM、19 nM、69 nM、69 nM の IC50 を持つ強力で選択性の高いヒストン リジン デメチラーゼ 5 (KDM5) 阻害剤です。 KDOAM-25クエン酸塩は、転写開始部位で全体的なH3K4メチル化を増加させ、多発性骨髄腫MM1S細胞の増殖を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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KDOAM-25 citrate is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].
[1]. Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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