Madrasin (Synonyms: DDD00107587) |
| رقم الكتالوجGC19238 |
Madrasin (DDD00107587) هو مثبط للربط يمنع تكوين كل من مواد التضفير الوسيطة والمنتجات في المختبر ويتداخل مع خطوة أو أكثر من الخطوات المبكرة في مسار التجميع الجسيمييمكن أن يمنع Madrasin أيضًا التضفير قبل mRNA في المختبر وتعديل التضفير لما قبل mRNA الداخلي في الخلايا
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 374913-63-0
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.
References:
[1]. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *