Madrasin (Synonyms: DDD00107587) |
| Catalog No.GC19238 |
Madrasin(DDD00107587)은 시험관 내에서 스플라이싱 중간체와 생성물 모두의 형성을 방지하고 스플라이세오솜 조립 경로에서 하나 이상의 초기 단계를 방해하는 스플라이싱 억제제입니다. Madrasin은 또한 시험관 내에서 pre-mRNA 스플라이싱을 억제하고 세포에서 내인성 pre-mRNA의 스플라이싱을 수정할 수 있습니다.
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Cas No.: 374913-63-0
Sample solution is provided at 25 µL, 10mM.
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Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.
References:
[1]. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.
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