Madrasin (Synonyms: DDD00107587) |
| Katalog-Nr.GC19238 |
Madrasin (DDD00107587) ist ein Splicing-Inhibitor, der die Bildung von Spleiß-Zwischenprodukten und -Produkten in vitro verhindert und einen oder mehrere frÜhe Schritte im Weg der Spleißosomen-Assemblierung stÖrt. Madrasin kann auch das Spleißen von prÄ-mRNA in vitro hemmen und das Spleißen von endogener prÄ-mRNA in Zellen modifizieren.
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Cas No.: 374913-63-0
Sample solution is provided at 25 µL, 10mM.
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Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.
References:
[1]. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.
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