Madrasin (Synonyms: DDD00107587) |
| Catalog No.GC19238 |
Madrasin (DDD00107587) es un inhibidor de empalme que previene la formaciÓn de productos e intermedios de empalme in vitro e interfiere con uno o mÁs pasos tempranos en la vÍa de ensamblaje del spliceosoma. Madrasin también puede inhibir el empalme de pre-ARNm in vitro y modificar el empalme de pre-ARNm endÓgeno en las células.
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Cas No.: 374913-63-0
Sample solution is provided at 25 µL, 10mM.
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Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.
References:
[1]. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.
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